Stephen Strange, an acclaimed neurosurgeon, loses the use of his hands in a car accident. Fellow surgeon and former lover Christine Palmer tries to help him move on, but Strange, firmly believing he can regain use of his hands, instead uses all his resources pursuing experimental surgeries in vain. After learning of Jonathan Pangborn, a paraplegic who mysteriously was able to walk again, Strange seeks him out, and is directed to Kamar-Taj. There, Strange is taken in by another sorcerer under the Ancient One, Mordo

En Sabah Nur, a supremely powerful mutant believed to be the very first of his kind, rules ancient Egypt until he is betrayed by his worshippers, who successfully attempt to bury him alive. His four lieutenants die preserving him. Awakening in Cairo in 1983, he believes humanity has turned to “false gods” in his absence. Aiming to save the world by destruction and remake it, he recruits pickpocket Ororo Munroe, who can control the weather, and further magnifies her abilities.

In 1991, the brainwashed super-soldier James “Bucky” Barnes is dispatched from a Hydra base in Siberia to intercept an automobile carrying a case of super-soldier serum. In the present day, approximately one year after Ultron’s defeat in the nation of Sokovia at the hands of the Avengers, Steve Rogers, Natasha Romanoff, Sam Wilson, and Wanda Maximoff stop Brock Rumlow from stealing a biological weapon from a lab in Lagos. Rumlow blows himself up, hoping to kill Rogers. When Maximoff tries to displace the blast into the sky with telekinesis, it destroys a nearby building, killing several Wakandan humanitarian workers.